c57 bl 6 mice  (Charles River Laboratories)

Journal: bioRxiv

Article Title: Cross-Fostering with control dams rescues Gut Dysbiosis and Chromatin-associated Transcriptional Changes in Offspring of Opioid-Exposed Dams

doi: 10.1101/2025.11.07.687278

Figure Lengend Snippet: (A) Schematic for FMT with stool samples from opioid dams or opioid and saline exposed dams into 3-week-old naïve C57BL/6 mice. (B) Representative H&E-stained small intestinal sections from: left panel) pups with FMT from hydromorphone exposed dams, right panel) pups with FMT from saline exposed and hydromorphone exposed dams in 1:1 ratio. Scale bar: 50 µM. (C) Graphs showing histopathological damage score in intestinal sections in different treatment groups. Data represented as bar plots with Standard error of mean (SEM). Data was analyzed by one-way ANOVA with Student T-Test (p<0.05) (D) Spearman’s Correlation analysis between bacterial taxa between HP_HM versus CP_CM with DEG |log2FC| ≥0.05 & p-value ≤0.05. Upregulated genes are indicated in Red while Blue indicated genes that are downregulated. (E) Spearman’s Correlation analysis between bacterial taxa between HP_CM versus HP_HM with DEG |log2FC| ≥0.05 & p-value ≤0.05. Upregulated genes are indicated in Red while Blue indicated genes that are downregulated.

Article Snippet: Twelve-week-old female C57 BL/6 mice (25-30g) were purchased from Jackson Laboratories (Bar Harbor, ME, USA) (strain 3752), with age-matched littermate wild type mice used as controls.

Techniques: Saline, Staining

Journal: Biomedicines

Article Title: Sex Differences in the Initiation and Progression of Necroptosis Following Kidney Ischemia–Reperfusion Injury

doi: 10.3390/biomedicines13092085

Figure Lengend Snippet: Schematic diagram of the study design. AKI was induced by bilateral renal pedicle clamping for 18 min followed by reperfusion for various time periods. A total of 40 male and 80 female C57 BL/6 J mice were allocated to male sham, male AKI, female sham, female AKI, ovariectomy AKI sham, and ovariectomy AKI groups ( n = 5/group at each time point).

Article Snippet: Male and female C57 BL/6 J mice (12 weeks old, weighing 25–32 g) were obtained from Jackson Laboratory (Bar Harbor, ME, USA).

Techniques: